Technology


Technology

NF-kB AND ITS POTENTIAL ROLE IN DRY EYE DISEASE (DED) INFLAMMATION


The NF-κB transcription factor is thought to play a role in DED as the inflammatory pathway may become activated through a number of different biological stimuli that may be commonly occurring on the ocular surface [6]. Signaling antagonists that activate the NF-κB transcription factor may include numerous growth factors, microbial byproducts, multiple cytokines, or UV irradiation. When activated, the NF-κB transcription factor may enter the cell nucleus and drive genetic transcription of additional inflammatory mediators such as MMP-9, various interleukin cytokines, and TNF-α, which may play a role in DED inflammation [7].

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SILK DERIVED PROTEIN-4 (SDP-4)

SilkTech has developed the patented Silk-Derived Protein (SDP) technology, which is a library of hydrolyzed proteins produced from the Bombyx mori silkworm cocoon [1]. SDP is unique in that the material is designed to be more soluble and stable in water than native silk proteins, thus more easily allowing their potential use in therapeutic formulations. Previous work has been performed to characterize their chemical structure and test them within various ocular surface models [2][3]. SDP-4 has been selected from the broader protein library for its use in the design of an eye drop product intended for treating Dry Eye Disease (DED).

Designed to treat the signs & symptoms of (DED)

SDP-4 offers a novel biotherapeutic approach as it is naturally derived from silk protein, and is designed to treat DED through a dual-mechanism of action to inhibit inflammation while physically improving tear film stability.

Novel biologic drug candidate that has been designed to work through a dual mechanism of action

SilkTech has repeatably demonstrated in an in-vitro cellular assay that SDP-4 may inhibit kinase activation of the NF-κB gene transcription pathway [4], which is a cellular signaling pathway that is thought to play a role in the production of pro-inflammatory mediators that may be involved in DED [5]. In addition, SDP-4’s inherent protein nature enhances spreading and wetting properties of aqueous formulations on hydrophobic surfaces. In that regard, SDP-4 is designed to act similar to mucin proteins which work to impart the spreading and wetting properties of natural tears on the hydrophobic ocular surface.

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NF-KB AND ITS POTENTIAL ROLE IN DRY EYE DISEASE (DED) INFLAMMATION


The NF-κB transcription factor is thought to play a role in DED as the inflammatory pathway may become activated through a number of different biological stimuli that may be commonly occurring on the ocular surface [6]. Signaling antagonists that activate the NF-κB transcription factor may include numerous growth factors, microbial byproducts, multiple cytokines, or UV irradiation. When activated, the NF-κB transcription factor may enter the cell nucleus and drive genetic transcription of additional inflammatory mediators such as MMP-9, various interleukin cytokines, and TNF-α, which may play a role in DED inflammation [7].

Image

SILK DERIVED PROTEIN-4 (SDP-4)


SilkTech has developed the patented Silk-Derived Protein (SDP) technology, which is a library of hydrolyzed proteins produced from the Bombyx mori silkworm cocoon [1]. SDP is unique in that the material is designed to be more soluble and stable in water than native silk proteins, thus more easily allowing their potential use in therapeutic formulations. Previous work has been performed to characterize their chemical structure and test them within various ocular surface models [2][3]. SDP-4 has been selected from the broader protein library for its use in the design of an eye drop product intended for treating Dry Eye Disease (DED).

Designed to treat the signs & symptoms of (DED)

SDP-4 offers a novel biotherapeutic approach as it is naturally derived from silk protein, and is designed to treat DED through a dual-mechanism of action to inhibit inflammation while physically improving tear film stability.

Novel biologic drug candidate that has been designed to work through a dual mechanism of action

SilkTech has repeatably demonstrated in an in-vitro cellular assay that SDP-4 may inhibit kinase activation of the NF-κB gene transcription pathway [4], which is a cellular signaling pathway that is thought to play a role in the production of pro-inflammatory mediators that may be involved in DED [5]. In addition, SDP-4’s inherent protein nature enhances spreading and wetting properties of aqueous formulations on hydrophobic surfaces. In that regard, SDP-4 is designed to act similar to mucin proteins which work to impart the spreading and wetting properties of natural tears on the hydrophobic ocular surface.

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